CU-CPT9a is a drug which acts as a potent and selective antagonist of Toll-like receptor 8 (TLR8), with an IC50 of 0.5nM. Activation of toll-like receptors triggers release of cytokines and other signalling factors, leading to inflammation. This is an essential part of the immune system's response to infection, but chronic activation of TLR signalling is thought to be involved in various inflammatory and autoimmune disorders. CU-CPT9a has immunosuppressant properties, and may have applications in the treatment of autoimmune disorders, as well as being used in scientific research into the function of TLR8.
"}{"slip": { "id": 188, "advice": "Measure twice, cut once."}}
{"fact":"The life expectancy of cats has nearly doubled since 1930 - from 8 to 16 years.","length":79}
{"slip": { "id": 137, "advice": "You're not that important; it's what you do that counts."}}
{"fact":"The cat's clavicle, or collarbone, does not connect with other bones but is buried in the muscles of the shoulder region. This lack of a functioning collarbone allows them to fit through any opening the size of their head.","length":222}
{"type":"standard","title":"Gruhalakshmi (1938 film)","displaytitle":"Gruhalakshmi (1938 film)","namespace":{"id":0,"text":""},"wikibase_item":"Q5609139","titles":{"canonical":"Gruhalakshmi_(1938_film)","normalized":"Gruhalakshmi (1938 film)","display":"Gruhalakshmi (1938 film)"},"pageid":24186508,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/8/80/Grihalakshmi_1938_Telugu_film.jpg/330px-Grihalakshmi_1938_Telugu_film.jpg","width":320,"height":244},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/8/80/Grihalakshmi_1938_Telugu_film.jpg","width":661,"height":505},"lang":"en","dir":"ltr","revision":"1252083694","tid":"5911cd9e-8e45-11ef-bd42-3b59c23d499b","timestamp":"2024-10-19T18:09:57Z","description":"1938 Indian film","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Gruhalakshmi_(1938_film)","revisions":"https://en.wikipedia.org/wiki/Gruhalakshmi_(1938_film)?action=history","edit":"https://en.wikipedia.org/wiki/Gruhalakshmi_(1938_film)?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Gruhalakshmi_(1938_film)"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Gruhalakshmi_(1938_film)","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Gruhalakshmi_(1938_film)","edit":"https://en.m.wikipedia.org/wiki/Gruhalakshmi_(1938_film)?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Gruhalakshmi_(1938_film)"}},"extract":"Gruhalakshmi is a 1938 Indian Telugu-language drama film produced and directed by H. M. Reddy. Starring Ramanujacharyulu, Kanchanamala, Kannamba, and Chittoor Nagayya, it was the debut production of Rohini Pictures and marked the cinematic debut of Chittoor Nagayya. The film was an adaptation of the 1929 stage play Rangoon Rowdy by Somaraju Ramanuja Rao and was a commercial success. Gruhalakshmi is notable for introducing Kanchanamala as Telugu cinema's first \"oomph\" girl, gaining widespread attention for its daring portrayal of sensuality. The film also marked an early career role for K. V. Reddy, who worked as a cashier for Rohini Pictures before becoming a renowned filmmaker.","extract_html":"
Gruhalakshmi is a 1938 Indian Telugu-language drama film produced and directed by H. M. Reddy. Starring Ramanujacharyulu, Kanchanamala, Kannamba, and Chittoor Nagayya, it was the debut production of Rohini Pictures and marked the cinematic debut of Chittoor Nagayya. The film was an adaptation of the 1929 stage play Rangoon Rowdy by Somaraju Ramanuja Rao and was a commercial success. Gruhalakshmi is notable for introducing Kanchanamala as Telugu cinema's first \"oomph\" girl, gaining widespread attention for its daring portrayal of sensuality. The film also marked an early career role for K. V. Reddy, who worked as a cashier for Rohini Pictures before becoming a renowned filmmaker.
"}{"slip": { "id": 210, "advice": "You never really grow up."}}
{"slip": { "id": 145, "advice": "Always the burrito."}}
{"type":"standard","title":"The Double Life of Veronique","displaytitle":"The Double Life of Veronique","namespace":{"id":0,"text":""},"wikibase_item":"Q1130211","titles":{"canonical":"The_Double_Life_of_Veronique","normalized":"The Double Life of Veronique","display":"The Double Life of Veronique"},"pageid":733176,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/en/8/81/The_Double_Life_of_V%C3%A9ronique.jpg","width":220,"height":294},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/en/8/81/The_Double_Life_of_V%C3%A9ronique.jpg","width":220,"height":294},"lang":"en","dir":"ltr","revision":"1283246163","tid":"d84f01d4-0e0a-11f0-b9e1-14605503ab65","timestamp":"2025-03-31T08:33:39Z","description":"1991 film by Krzysztof Kieślowski","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/The_Double_Life_of_Veronique","revisions":"https://en.wikipedia.org/wiki/The_Double_Life_of_Veronique?action=history","edit":"https://en.wikipedia.org/wiki/The_Double_Life_of_Veronique?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:The_Double_Life_of_Veronique"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/The_Double_Life_of_Veronique","revisions":"https://en.m.wikipedia.org/wiki/Special:History/The_Double_Life_of_Veronique","edit":"https://en.m.wikipedia.org/wiki/The_Double_Life_of_Veronique?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:The_Double_Life_of_Veronique"}},"extract":"The Double Life of Veronique is a 1991 drama film directed by Krzysztof Kieślowski, and starring Irène Jacob and Philippe Volter. Written by Kieślowski and Krzysztof Piesiewicz, the film explores the themes of identity, love, and human intuition through the characters of Weronika, a Polish choir soprano, and her double, Véronique, a French music teacher. Despite not knowing each other, the two women share a mysterious and emotional bond that transcends language and geography.","extract_html":"
The Double Life of Veronique is a 1991 drama film directed by Krzysztof Kieślowski, and starring Irène Jacob and Philippe Volter. Written by Kieślowski and Krzysztof Piesiewicz, the film explores the themes of identity, love, and human intuition through the characters of Weronika, a Polish choir soprano, and her double, Véronique, a French music teacher. Despite not knowing each other, the two women share a mysterious and emotional bond that transcends language and geography.
"}